Reacción #576256

Ecuación de reacción

Benzyl bromide

2-hydroxystearic acid

potassium tert-butoxide

→

benzyl 2-hydroxystearate

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred for six hours at 80° C
2. 2
   OtroThe mixture was evaporated under reduced pressure and 100 ml ethyl acatate
3. 3
   workup.ADDITIONwas added
4. 4
   OtroThe organic phase was separated
5. 5
   Lavadowashed four times with water
6. 6
   SecadoThe organic phase was dried with sodium sulfate
7. 7
   Concentraciónconcentrated in vacuo
8. 8
   OtroThe product was isolated by silica gel column chromatography

Procedimiento

To a stirred solution of DL-2-hydroxystearic acid (3.0 g, 10 mmole) in 20 ml dry DMF was added potassium tert-butoxide (1.23 g, 11 mmole) and the mixture was stirred for one hour at 60° C. Benzyl bromide (2.14 g, 12.5 mmole) was added and the mixture was stirred for six hours at 80° C. The mixture was evaporated under reduced pressure and 100 ml ethyl acatate was added. The organic phase was separated and washed four times with water. The organic phase was dried with sodium sulfate and concentrated in vacuo. The product was isolated by silica gel column chromatography. Yield: 3.3 g

Fuente