Reacción #575578

Ecuación de reacción

4-chlorobenzylisocyanate

1-(4-chlorobenzyl)piperazine

→

1-(((4-chlorobenzyl)amino)carbonyl)-4-(4-chlorobenzyl)piperazine

Rendimiento 54.4%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónAfter 20 hours the mixture was concentrated of volatiles
2. 2
   LavadoThe resulting solid was washed with ethyl acetate
3. 3
   Otrodried in vacuo

Procedimiento

To a solution of 4-chlorobenzylisocyanate (0.59 g, 3.5 mmol) in anhydrous THF (15 mL) at 0° C. was added 1-(4-chlorobenzyl)piperazine (0.74 g, 3.5 mmol). The resultant mixture was stirred at ambient temperature. After 20 hours the mixture was concentrated of volatiles. The resulting solid was washed with ethyl acetate and dried in vacuo to afford 0.72 g of 1-(((4-chlorobenzyl)amino)carbonyl)-4-(4-chlorobenzyl)piperazine as a white solid; NMR (CDCl3) 7.4 (m, 4), 7.3 (m, 2), 7.2 (m, 2), 4.4-4.1 (m, 6), 3.6 (m, 4), 3.0 (m, 2) ppm.

Fuente