Reacción #575314

Ecuación de reacción

(Z)-3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-2-methylpropenoic acid

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titled compound

Rendimiento 87.4%

(Z)-3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthyl)-2-methylpropenoic acid

Rendimiento 87.4%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrohas been preliminarily bubbled
2. 2
   workup.ADDITION43 ml of concentrated hydrochloric acid was gradually added
3. 3
   workup.STIRRINGAfter stirring at room temperature for 1.5 hours
4. 4
   workup.ADDITIONthe reaction mixture was gradually poured into water
5. 5
   Otroto crystalize
6. 6
   FiltraciónThe crystals were filtered
7. 7
   Lavadowashed with water
8. 8
   Otrodried

Procedimiento

66 g of (Z)-3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-2-methylpropenoic acid was dissolved in 700 ml of acetone in which nitrogen has been preliminarily bubbled, and 43 ml of concentrated hydrochloric acid was gradually added while stirring at room temperature in a stream of nitrogen under light-shielded conditions. After stirring at room temperature for 1.5 hours, the reaction mixture was gradually poured into water to crystalize. The crystals were filtered, washed with water and dried to obtain 50.0 g of the titled compound as yellow crystals.

Fuente