Reacción #572011

Ecuación de reacción

1-(2-phenoxyethyl)piperidine

hydrobromic acid

→

1-(2-bromoethyl)piperidine hydrobromide

Rendimiento 79.0%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction solution was cooled
2. 2
   Otrothe chloroform layer was separated
3. 3
   Otrocondensed under reduced pressure
4. 4
   Otrothe residue was recrystallized from 5 ml of ethyl alcohol

Procedimiento

15 g of the 1-(2-phenoxyethyl)piperidine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled, added with 20 ml of chloroform and then the chloroform layer was separated. The hydrobromic acid layer was condensed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 15.1 g of 1-(2-bromoethyl)piperidine hydrobromide having a melting point of 89° C. to 91° C. in a yield of 79%.

Fuente