Reacción #57125

ord-66cf7ebbdfce409ca868c0b8329f6ff6

Ecuación de reacción

CN1CCN(CC(c2ccc(OCc3ccc(C(F)(F)F)cc3)c(F)c2)C2(O)CCCCC2)CC1.Cl.Cl
1-[1-(3-fluoro-4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride
Cc1ccc(COc2ccc(C(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)C3(O)CCCCC3)cc2F)cc1
tert-butyl 4-[(3-fluoro-4-{[4-(methyl)benzyl]oxy}phenyl)(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate
→
Cc1ccc(COc2ccc(C(CN3CCNCC3)C3(O)CCCCC3)cc2F)cc1.Cl.Cl
1-(1-{3-fluoro-4-[(4-methylbenzyl)oxy}phenyl]-2-piperazin-1-ylethyl)cyclohexanol Dihydrochloride

Reactantes

CN1CCN(CC(c2ccc(OCc3ccc(C(F)(F)F)cc3)c(F)c2)C2(O)CCCCC2)CC1.Cl.Cl
1-[1-(3-fluoro-4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride
Cc1ccc(COc2ccc(C(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)C3(O)CCCCC3)cc2F)cc1
tert-butyl 4-[(3-fluoro-4-{[4-(methyl)benzyl]oxy}phenyl)(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

In an analogous manner to Example 1, step 2 1-[1-(3-fluoro-4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl 4-[(3-fluoro-4-{[4-(methyl)benzyl]oxy}phenyl)(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate. MS (ESI) m/z 427; HRMS: calcd for C26H35FN2O2+H+, 427.27553; found (ESI, [M+H]+), 427.2776.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07419980B2uspto-grants-2008_09