Reacción #5705

Ecuación de reacción

methyl α-[3-(trifluoromethyl)benzylamino]-1-benzylindole-3-acetate

hydrogen chloride

→

title compound

Rendimiento 95.0%

Methyl α-[3-(trifluoromethyl)benzylamino]-1-benzylindole-3-acetate hydrochloride

Rendimiento 95.0%

Disolventes

ether

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe cooling bath was removed
2. 2
   workup.ADDITIONafter addition
3. 3
   OtroThe precipitated white solid was collected
4. 4
   Lavadowashed with ether-hexane (1:1)
5. 5
   Otrorecrystallized from acetone-ethyl acetate-ether solvent mixture

Procedimiento

A magnetically stirred solution of methyl α-[3-(trifluoromethyl)benzylamino]-1-benzylindole-3-acetate (4.07 g, 9.0 mmol) in 65 mL of ether cooled at 0°-5° C. was treated dropwise over a four-minute period with a stock solution of hydrogen chloride in ether (3.8 mL, 11.71 mmol, 1.3 eq, 3.1 mmol per mL). The cooling bath was removed after addition was completed and the mixture stirred at room temperature overnight. The precipitated white solid was collected, washed with ether-hexane (1:1) and recrystallized from acetone-ethyl acetate-ether solvent mixture to yield 4.18 g (95%) of the title compound.

Fuente