Reacción #57044

Ecuación de reacción

Boc-Tyr-OH

N-hydroxysuccinamide

gabapentin

sodium hydroxide

→

Boc-Tyr Gabapentin

Rendimiento 106.7%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe resulting mixture stirred at ambient temperature for 16 h
2. 2
   ConcentraciónThe reaction was concentrated under reduced pressure
3. 3
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate/diethyl ether (1/1, 200 mL)
4. 4
   Lavadowashed with 0.1M aqueous potassium hydrogensulfate (2×200 mL)
5. 5
   OtroThe organic phase was separated
6. 6
   Secadodried over Na2SO4
7. 7
   Filtraciónfiltered
8. 8
   Concentraciónconcentrated to dryness under reduced pressure

Procedimiento

To a solution of Boc-Tyr-OH (4.2 g, 15 mmol) in acetonitrile (100 mL) was added N-hydroxysuccinamide (1.84 g, 16 mmol) and N,N-dicyclohexylcarbodiimide (3.3 g, 16 mmol). The reaction was stirred at ambient temperature for 2 h. The reaction mixture was filtered directly into an aqueous solution (100 mL) of gabapentin (2.7 g, 16 mmol) and sodium hydroxide (640 mg, 16 mmol), and the resulting mixture stirred at ambient temperature for 16 h. The reaction was concentrated under reduced pressure, the residue was dissolved in ethyl acetate/diethyl ether (1/1, 200 mL) and washed with 0.1M aqueous potassium hydrogensulfate (2×200 mL). The organic phase was separated, dried over Na2SO4, filtered, and concentrated to dryness under reduced pressure to afford Boc-Tyr-Gabapentin as a white solid (7.4 g, 16 mmol).

Fuente