Reacción #5704

ord-9d6b4639e61f428789f790c938140d8e

Ecuación de reacción

COC(=O)C(NCc1cccc(C(F)(F)F)c1)c1cn(Cc2ccccc2)c2ccccc12.Cl
methyl α-[3-(trifluoromethyl)benzylamino-]-1-benzylindole-3-acetate hydrochloride
C[O-].[Na+]
sodium methoxide
→
CCOC(=O)C(NCc1cccc(C(F)(F)F)c1)c1cn(Cc2ccccc2)c2ccccc12
title compound
CCOC(=O)C(NCc1cccc(C(F)(F)F)c1)c1cn(Cc2ccccc2)c2ccccc12
Ethyl α-[3-(trifluoromethyl)benzylamino]-1-benzylindole-3-acetate

Reactantes

COC(=O)C(NCc1cccc(C(F)(F)F)c1)c1cn(Cc2ccccc2)c2ccccc12.Cl
methyl α-[3-(trifluoromethyl)benzylamino-]-1-benzylindole-3-acetate hydrochloride
C[O-].[Na+]
sodium methoxide

Reactivos

Ninguno

Disolventes

CCO
ethanol
CO
methanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

To a magnetically stirred solution of methyl α-[3-(trifluoromethyl)benzylamino-]-1-benzylindole-3-acetate hydrochloride (100 mg) in 8 mL of ethanol was added 70 μL of 25% sodium methoxide in methanol. After stirring at room temperature for two hours, TLC analysis showed 90% conversion to the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05245046uspto-grants-1993_09