Reacción #569915

Ecuación de reacción

ether

3-azido-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one

ethanol

→

3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one

Disolventes

water

—

2B

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   workup.ADDITIONwas added
3. 3
   Filtraciónthe catalyst was filtered off
4. 4
   Otrothe solvent removed under reduced pressure
5. 5
   Otroto give an oil which

Procedimiento

To a solution of 3-azido-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (see Example 1) (27 g) in 2B ethanol (3500 ml) stirring at room temperature under an atmosphere of nitrogen, a suspension of Raney nickel in water (50 ml, washed with 10 volumes of ethanol) was added. The mixture was stirred at room temperature for 2 hours when an additional 30 ml of Raney nickel suspension was added. After stirring for an additional 30 minutes, the catalyst was filtered off and the solvent removed under reduced pressure to give an oil which solidified on addition of ether to give 3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one, melting at 161°-2°.

Fuente