Reacción #56853
ord-29ed1b24e7cc4ae08ed130bef687e9f1
Ecuación de reacción
4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine
4-methoxy-phenylamine
→
title compound
Rendimiento 61.0%
6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-methoxy-phenyl)-pyrimidine-2,4-diamine
Rendimiento 61.0%
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-methoxy-phenylamine provided the title compound (61% yield). 1H NMR (DMSO-d6) δ 1.34 (t, 3H, J=6.9 Hz, CH3), 3.74 (s, 3H, CH3), 4.10 (q, 2H, J=7.0 Hz, CH2), 6.18 (s, 2H, NH2), 6.71 (s, 1H, Ar), 6.89 (d, 2H, J=8.6 Hz, Ar), 7.12 (d, 1H, J=8.9 Hz, Ar), 7.39 (dd, 1H, J=8.8 Hz, 2.9 Hz, Ar), 7.53 (d, 2H, J=8.6 Hz, Ar), 7.94 (d, 1H, J=2.8 Hz, Ar), 8.93 (s, 1H, NH).