Reacción #5674

Ecuación de reacción

oxazolidinone

diethyl bromomalonate

potassium carbonate

acetone

→

1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered
2. 2
   Lavadowashed with acetone
3. 3
   Otroevaporated to a brown oil
4. 4
   OtroThe oil is purified by flash chromatography
5. 5
   Lavadoeluting with 5 percent acetone in toluene
6. 6
   Otroevaporated

Procedimiento

A mixture of 240 mg of the above oxazolidinone, 234 mg of diethyl bromomalonate, 450 mg of anhydrous potassium carbonate and 10 ml of acetone is stirred overnight, filtered, washed with acetone and evaporated to a brown oil. The oil is purified by flash chromatography, eluting with 5 percent acetone in toluene. The pure fractions are combined and evaporated giving 237 mg of (R,R)-5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester as a colorless oil.

Fuente