Reacción #56590

Ecuación de reacción

2-(6-chlorohexyloxy)tetrahydropyrane

hydroquinone

potassiumcarbonate

potassiumiodide

→

product

Rendimiento 82.5%

4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

Rendimiento 82.5%

Disolventes

dimethylsulfoxide

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto react for 4 days at 80° C
2. 2
   Extracciónextracted with ether
3. 3
   SecadoThe organic phase was then dried over sodium sulphate
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated to dryness

Procedimiento

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

Fuente