Reacción #565485

Ecuación de reacción

product

Methyl [(1-methyl-2-propynyl)oxy]acetate

methanol

→

title compound

Methyl (1-methyl-2-oxopropoxy)acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturato reflux for 1 hour
3. 3
   Concentraciónconcentrated to approximately 100 mL total volume
4. 4
   workup.ADDITIONtreated with 1M HCl (100 mL)
5. 5
   Extracciónextracted with dichloromethane (3×, 100 mL)
6. 6
   ExtracciónThe extractions
7. 7
   Secadodried (MgSO4)
8. 8
   Filtraciónfiltered
9. 9
   Concentraciónconcentrated

Procedimiento

The product from Example 84A (20 g, 0.14 mol) in methanol (700 mL) was treated with mercury(II) acetate (4.6 g, 0.014 mol), heated to reflux for 1 hour, concentrated to approximately 100 mL total volume, treated with 1M HCl (100 mL) and extracted with dichloromethane (3×, 100 mL). The extractions were combined, dried (MgSO4), filtered and concentrated to provide the title compound.

Fuente