Reacción #56542

Ecuación de reacción

2-cyano-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethanol

methane sulfonyl chloride

triethylamine

→

2-cyano-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethyl methane sulfonate

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated on a steam bath for another 30 minutes
2. 2
   OtroThe precipitate formed
3. 3
   Filtraciónis filtered
4. 4
   Lavadothe filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution
5. 5
   Secadodried over magnesium sulfate
6. 6
   OtroThe solvent is evaporated
7. 7
   Otroto give 22 g

Procedimiento

To a mixture of 2-cyano-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethanol (18 g., 0.06 mole) and methane sulfonyl chloride (7.8 g., 0.07 mole) in 200 ml. of benzene is added dropwise at 10° C., 7.5 g. (0.08 mole) of triethylamine. The reaction mixture is stirred at room temperature for 30 minutes and then heated on a steam bath for another 30 minutes. The precipitate formed is filtered and the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 22 g. of product; mp 124°-7° C., which is identified by nmr.

Fuente