Reacción #56536

Ecuación de reacción

α-n-octyl-2,4-dichlorobenzyl cyanide

pyridine

paraformaldehyde

benzyl triethylammonium hydroxide

→

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONis added 1 ml
2. 2
   Extracciónextracted with ether
3. 3
   LavadoThe combined ether extracts are washed with water, saturated sodium chloride solution
4. 4
   Secadodried over magnesium sulfate
5. 5
   OtroThe solvent is evaporated
6. 6
   Otroto give 40 g

Procedimiento

To an ice cold stirred solution of α-n-octyl-2,4-dichlorobenzyl cyanide (40 g., 0.14 mole) in 250 ml. of pyridine containing a suspension of paraformaldehyde (21 g., 0.7 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 72 hours. The reaction mixture is poured into 2 liters of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 40 g. of a thick oil.

Fuente