Reacción #565255

ord-ace3d167981649f5b92a1c86044c0fb5

Ecuación de reacción

O=C1CCCCC1O
2-hydroxycyclohexanone
CC(C)[N-]C(C)C.[Li+]
LDA
C=CC(=O)CC
methylbutenone
[K+].[OH-]
KOH
CC1=C(C)C(=O)CCC1
2,3-dimethylcyclohexenone
→
CC1CC2=CCCCC2=CC1=O
3-Methyl-4,6,7,8-tetrahydro-2(3H)-naphthalenone

Reactantes

O=C1CCCCC1O
2-hydroxycyclohexanone
CC(C)[N-]C(C)C.[Li+]
LDA
C=CC(=O)CC
methylbutenone
[K+].[OH-]
KOH
CC1=C(C)C(=O)CCC1
2,3-dimethylcyclohexenone

Reactivos

Ninguno

Disolventes

CO
MeOH
C1CCOC1
THF

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThis material is prepared

Procedimiento

This material is prepared according to the procedure for Preparation 5 wherein 2-hydroxycyclohexanone is substituted for 2,3-dimethylcyclohexenone, methylbutenone is substituted for MVK, and 2N KOH in MeOH is substituted fro LDA in THF.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04889947uspto-grants-1989_12