Reacción #565233

Ecuación de reacción

2-chloromethyl quinoline

amino guanidine bicarbonate

→

product

Rendimiento 65.0%

2-[1-[3-(2-Quinolinylmethoxy)phenyl]ethylidene]hydrazinecarboximidamide

Rendimiento 65.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrois prepared (13.1 g, m.p. 57°-59° C., 47% yield)

Procedimiento

In a similar manner to Example 1A and using 2-chloromethyl quinoline, 3-(2-quinolinylmethoxy)acetophenone is prepared (13.1 g, m.p. 57°-59° C., 47% yield). This product is reacted with amino guanidine bicarbonate as in 1B above to give 2.35 g of product (65% yield), m.p. 168°-170° C.

Fuente