Reacción #56499

Ecuación de reacción

diazomethane

4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoic acid

Acetic acid

→

title compound

Methyl 4-{3-[3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoate

Disolventes

ether

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto destroy the excess diazomethane
2. 2
   Lavadothe solution is washed with dilute sodium bicarbonate solution
3. 3
   Secadodried over sodium sulfate
4. 4
   OtroEvaporation of volatile materials in vacuo

Procedimiento

A solution of diazomethane (approximately 2.5 g., 0.06 mole) in ether (100 ml.) is mixed with a solution of 4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoic acid (11.7 g., 0.03 mole) in ether (100 ml.). The resulting solution is allowed to stand at room temperature for 6 hours. Acetic acid is then added to destroy the excess diazomethane, and the solution is washed with dilute sodium bicarbonate solution and dried over sodium sulfate. Evaporation of volatile materials in vacuo yields the title compound as a nearly colorless, viscous oil.

Fuente