Reacción #56364

Ecuación de reacción

HCl

1-methylethyl 2.2-dichloro-2[(1-methylethoxy)phenylphosphinyl]acetate

n-butyl lithium

→

1-methylethyl 2-chloro-2[(1-methylethoxy)phenylphosphinyl]acetate

Rendimiento 78.0%

Disolventes

ether

hexane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato warm to -10°
2. 2
   OtroThe phases were separated
3. 3
   Lavadothe organic phase washed with water
4. 4
   OtroThe solution was then dried

Procedimiento

To a solution of 7.1 g of 1-methylethyl 2.2-dichloro-2[(1-methylethoxy)phenylphosphinyl]acetate in 150 ml of ether was added 14 ml of a solution of 1.6 M n-butyl lithium in hexane at -70° over 15 minutes. The solution was then allowed to warm to -10° before adding 60 ml of 0.5 M aqueous HCl solution at -10° to 0°. The phases were separated and the organic phase washed with water then 5% NaHCO3 solution. The solution was then dried and stripped to give 5.0 g of 1-methylethyl 2-chloro-2[(1-methylethoxy)phenylphosphinyl]acetate as a light yellow oil ND25 1.5057.

Fuente