Reacción #56312

Ecuación de reacción

2-Methoxyaniline

sodium carbonate

2-Bromomethyl-4,5-dimethyl-1,3-dioxolane

→

N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroequipped with a mechanical stirrer
2. 2
   Temperaturathermometer and reflux condenser
3. 3
   FiltraciónAfter this time the reaction mixture was filtered
4. 4
   workup.ADDITIONadditional sodium carbonate (5.00 grams) was added to the filtrate
5. 5
   workup.DISTILLATIONThe mixture was then distilled under reduced pressure

Procedimiento

2-Methoxyaniline (87 ml; 0.7 mole) and sodium carbonate (31.66 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4,5-dimethyl-1,3-dioxolane (25 mls) was added and the reaction mixture was heated at a temperature of 100° C. for a period of about 4 hours. After this time the reaction mixture was filtered and additional sodium carbonate (5.00 grams) was added to the filtrate. The mixture was then distilled under reduced pressure to yield the desired product N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline boiling at 125° to 128° C. at 0.1 mm of Hg pressure.

Fuente