Reacción #56282

Ecuación de reacción

3-chlorosulfonylthiophene-2-carboxylic acid chloride

methanol

hydrogen chloride

→

3-chlorosulfonylthiophene-2-carboxylic acid methyl ester

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture is heated
2. 2
   OtroThe mixture is evaporated to dryness in vacuo
3. 3
   Otroto crystallize

Procedimiento

48 G. (0.196 mol) of the obtained 3-chlorosulfonylthiophene-2-carboxylic acid chloride are dissolved in 500 ml. of absolute chloroform, 9.6 g. (0.3 mol) of absolute methanol are added and the mixture is heated to reflux for 3 hours [until no more hydrogen chloride evolution]. The mixture is evaporated to dryness in vacuo and the residue allowed to crystallize. There is obtained pure 3-chlorosulfonylthiophene-2-carboxylic acid methyl ester.

Fuente