Reacción #56278

Ecuación de reacción

3-sulfothiophene-2-carboxylic acid methyl ester

thionyl chloride

→

3-chlorosulfonylthiophene-2-carboxylic acid methyl ester

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux for 16 hours
2. 2
   OtroThe mixture is then evaporated to dryness in vacuo
3. 3
   Otrothe remaining bright-yellow oil is brought to crystallization with petroleum ether

Procedimiento

7.4 G. of crude 3-sulfothiophene-2-carboxylic acid methyl ester are dissolved in 50 ml. of thionyl chloride and boiled to reflux for 16 hours. The mixture is then evaporated to dryness in vacuo and the remaining bright-yellow oil is brought to crystallization with petroleum ether. There is obtained 3-chlorosulfonylthiophene-2-carboxylic acid methyl ester.

Fuente