Reacción #56259

Ecuación de reacción

adenosine-5'-carboxylic acid methyl ester

hydrazine hydrate

→

adenosine-5'-carboxylic acid hydrazide

Rendimiento 93.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated to the boil
2. 2
   Otrowhile, almost simultaneously, the hydrazide precipitates out in the form of a fine crystalline material
3. 3
   Filtraciónit is filtered off with suction
4. 4
   Lavadowashed with methanol
5. 5
   Otrodried

Procedimiento

5 g of adenosine-5'-carboxylic acid methyl ester are suspended in 150 ml of methanol mixed with 20 ml of hydrazine hydrate and heated to the boil. The ester thereby goes into solution, while, almost simultaneously, the hydrazide precipitates out in the form of a fine crystalline material. After standing overnight, it is filtered off with suction, washed with methanol and dried. There are obtained 4.4 g of adenosine-5'-carboxylic acid hydrazide, which melts, with decomposition, at 270°-272° C. The yield is 93% of theory. The compound can be readily recrystallized from hot water.

Fuente