Reacción #56255

Ecuación de reacción

adenosine-5'-carboxylic acid methyl ester

n-butanol

→

crude product

Rendimiento 87.0%

Adenosine-5'-carboxylic acid n-butyl ester

Rendimiento 87.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 3 hours
2. 2
   FiltraciónThe reaction mixture is filtered
3. 3
   Otrothe filtrate evaporated in a vacuum
4. 4
   OtroThe evaporation residue is triturated with ether
5. 5
   Filtraciónfiltered off with suction
6. 6
   Lavadoagain washed with ether
7. 7
   Otrodried

Procedimiento

5 g of adenosine-5'-carboxylic acid methyl ester are dissolved in 200 ml of n-butanol and, together with 3 g of D-benzedrine, boiled under reflux for 3 hours. The reaction mixture is filtered and the filtrate evaporated in a vacuum. The evaporation residue is triturated with ether, filtered off with suction, again washed with ether and dried. There are thus obtained 5.6 g of adenosine-5'-carboxylic acid n-butyl ester, which has a melting point of 166°-167° C. The yield is 87% of theory. The crude product obtained can be recrystallized from water.

Fuente