Reacción #56222

ord-b5f20582738f406eb6b3c78ee652cf93

Ecuación de reacción

CC(C)C(C(=O)O)c1cc2cc(Cl)ccc2s1
2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid
OCc1[nH]ccc1Cc1ccc(F)cc1
3-(4-fluorobenzyl)-pyrrolylmethyl alcohol
→
CC(C)C(C(=O)OCc1[nH]ccc1Cc1ccc(F)cc1)c1cc2cc(Cl)ccc2s1
3-(4-fluorobenzyl)-pyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

Reactantes

—
acid chloride
CC(C)C(C(=O)O)c1cc2cc(Cl)ccc2s1
2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid
OCc1[nH]ccc1Cc1ccc(F)cc1
3-(4-fluorobenzyl)-pyrrolylmethyl alcohol

Reactivos

Ninguno

Disolventes

CCOCC
ether

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The acid chloride of 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid is reacted with 3-(4-fluorobenzyl)-pyrrolylmethyl alcohol in ether as in Example 20 to give 3-(4-fluorobenzyl)-pyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04224330uspto-grants-1980_09