Reacción #56208

Ecuación de reacción

methylene chloride

2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid

K2CO3

α-cyano-3-phenoxybenzyl chloride

→

α-cyano-3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

Disolventes

DMSO

ether

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroreaction mixture
2. 2
   workup.STIRRINGstirred for about 48 hours
3. 3
   Lavadowashed with water and brine
4. 4
   Secadodried over Na2SO4 and solvent
5. 5
   Otroremoved

Procedimiento

A mixture of 10 ml methylene chloride, 10 ml THF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.25 g) and α-cyano-3-phenoxybenzyl chloride (0.42 g) is stirred at RT for 15 hours. Then 5 ml of DMSO is added and reaction mixture stirred for about 48 hours. The mixture is taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ethyl acetate/hexane to give α-cyano-3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

Fuente