Reacción #561836

Ecuación de reacción

ethyl trifluoroacetate

1,3-diamino-2-propanol

→

title compound

Rendimiento 97.5%

2-(trifluoromethyl)-1,4,5,6-tetrahydro-5-pyrimidinol

Rendimiento 97.5%

Disolventes

p-Xylene

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónConcentration in vacuo

Procedimiento

To a solution of ethyl trifluoroacetate (5.80 g, 40.8 mmol) in p-Xylene (30 mL) was added 1,3-diamino-2-propanol (3.60 g, 40 mmol). The mixture was stirred at 160° C. for 4 h. Concentration in vacuo then afforded the title compound (6.55 g, 39.0 mmol, 97% yield).

Fuente