Reacción #5614

Ecuación de reacción

5-benzyloxy-2-hydroxymethyl-4-pyridone

thionyl chloride

→

5-benzyloxy-2-chloromethyl-4-pyridone

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGAfter being stirred at the same temperature for 30 minutes
2. 2
   Temperaturathe mixture was refluxed for 4 hours
3. 3
   FiltraciónThe precipitate was collected by filtration
4. 4
   Lavadowashed with benzene
5. 5
   Otrodried under reduced pressure

Procedimiento

To a suspension of 5-benzyloxy-2-hydroxymethyl-4-pyridone (33 g) in benzene (500 ml) was added thionyl chloride (28.4 ml) at ambient temperature under stirring. After being stirred at the same temperature for 30 minutes, the mixture was refluxed for 4 hours. The resulting mixture was cooled to ambient temperature. The precipitate was collected by filtration, washed with benzene and dried under reduced pressure to give 5-benzyloxy-2-chloromethyl-4-pyridone (41.5 g).

Fuente