Reacción #5610

Ecuación de reacción

5-benzyloxy-2-vinyl-4-pyridone

pyrrolidine

→

5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

Disolventes

tetrahydrofuran

diisopropyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturarefluxed for an hour
3. 3
   TemperaturaThe mixture was cooled
4. 4
   Filtraciónthe resulting precipitate was collected by filtration
5. 5
   Lavadowashed with diisopropyl ether
6. 6
   Otroair-dried at ambient temperature

Procedimiento

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

Fuente