Reacción #5608

Ecuación de reacción

2-chloromethyl-5-benzyloxy-4-pyridone

tetrahydrofuran

dimethylamine hydrochloride

sodium hydroxide

→

5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

Rendimiento 96.7%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthe mixture was concentrated under reduced pressure to dryness
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methanol
3. 3
   Filtraciónthe insoluble material was filtered off
4. 4
   OtroThe filtrate was evaporated in vacuo

Procedimiento

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g), tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g). After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

Fuente