Reacción #55957

Ecuación de reacción

2-Bromo-4,6-dinitro-2'-acetylamino-4'-(N,N-diethylamino)azobenzene

sodium acetate

formamide

propionic anhydride

→

2-cyano-4,6-dinitro-2'-acetylamino-4'-(N,N-diethylamino)azobenzene

Rendimiento 83.5%

Disolventes

n-butyl acetate

—

petroleum ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaare heated
2. 2
   TemperaturaThe temperature is maintained for 30 minutes
3. 3
   Otrowhen reaction
4. 4
   TemperaturaThe mixture is cooled to room temperature
5. 5
   OtroThe precipitate is collected
6. 6
   Lavadowashed with petroleum ether (100 parts)
7. 7
   Otrodried

Procedimiento

2-Bromo-4,6-dinitro-2'-acetylamino-4'-(N,N-diethylamino)azobenzene (2.4 parts), copper (I) iodide (0.95 parts), anhydrous sodium acetate (1.2 parts), formamide (1.8 parts), propionic anhydride (2.6 parts) and n-butyl acetate (44 parts) are mixed together are heated, with stirring, to 110° C. during 15 minutes. The temperature is maintained for 30 minutes when reaction is adjudged complete by thin layer chromatography. The mixture is cooled to room temperature and poured into petroleum ether (boiling range 60-80° C.) (400 parts). The precipitate is collected, washed with petroleum ether (100 parts) and dried. 2-cyano-4,6-dinitro-2'-acetylamino-4'-(N,N-diethylamino)azobenzene is obtained in 83.5% yield.

Fuente