Reacción #55869

Ecuación de reacción

Thiophene

trichloroacetaldehyde

→

α-trichloromethyl-2-thiophenemethanol

Rendimiento 20.0%

Disolventes

n-heptane

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe solution was heated
2. 2
   Temperaturaunder reflux for 3.5 hr
3. 3
   TemperaturaAfter cooling
4. 4
   Concentraciónthe n-heptane solution was concentrated
5. 5
   workup.DISTILLATIONthe residue was purified by distillation

Procedimiento

Thiophene (4.2 g, 50 mmol) and trichloroacetaldehyde (7.35 g, 50 mmol) were dissolved in n-heptane (25 ml). The solution was heated under reflux for 3.5 hr. under a Soxleht apparatus in which Amberlyst 15 (4.2 g) had been placed. After cooling, the n-heptane solution was concentrated, and the residue was purified by distillation to give 2.32 g of α-trichloromethyl-2-thiophenemethanol boiling at 98°-100° C./1.0 mmHg.

Fuente