Reacción #55771

Ecuación de reacción

2-mercaptoimidazole

3-aminopropanol

hydrobromic acid

→

2-(3-aminopropylthio)imidazole dihydrobromide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 25 hours
2. 2
   OtroThe reaction mixture was evaporated to dryness
3. 3
   Otrothe oily residual solid recrystallised twice from ethanol/ether

Procedimiento

A solution of 2-mercaptoimidazole (2 g.) and 3-aminopropanol (1.14 ml.) in hydrobromic acid (48%, 25 ml.) was heated under reflux for 25 hours. The reaction mixture was evaporated to dryness and the oily residual solid recrystallised twice from ethanol/ether to give 2-(3-aminopropylthio)imidazole dihydrobromide (3.55 g.), m.p. 160°-162°.

Fuente