Reacción #55767

Ecuación de reacción

Sulphuryl chloride

ethyl 3-oxopentanoate

→

ethyl 2-chloro-3-oxopentanoate

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONaddition the mixture
2. 2
   Temperaturaheated
3. 3
   Temperaturaunder reflux for 0.5 hour
4. 4
   Temperaturacooled
5. 5
   LavadoAfter washing with water, sodium bicarbonate and water
6. 6
   Secadothe solution was dried (sodium sulphate)
7. 7
   Concentraciónconcentrated

Procedimiento

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

Fuente