Reacción #556515

Ecuación de reacción

3-bromo-4-fluoro-benzoic acid chloride

4-methyl-3H-benzoxazol-2-one

aluminium trichloride

→

6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe precipitate formed
2. 2
   Filtraciónfiltered
3. 3
   Lavadowashed with water
4. 4
   OtroThen the precipitate was triturated with MeOH, suction
5. 5
   Filtraciónfiltered
6. 6
   Lavadowashed with MeOH
7. 7
   Otrodried i

Procedimiento

2.23 g (9.40 mmol) 3-bromo-4-fluoro-benzoic acid chloride, 1.40 g (9.40 mmol) 4-methyl-3H-benzoxazol-2-one and 5.01 g (37.60 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered and washed with water. Then the precipitate was triturated with MeOH, suction filtered, washed with MeOH and dried i. vac.

Fuente