Reacción #556478

Ecuación de reacción

6-chloropyrimidine-4-carboxylic acid chloride

aluminium trichloride

4-methyl-3H-benzoxazol-2-one

→

6-(6-chloropyrimidine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to RT the mixture
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   Otrothe organic phase was dried on sodium sulphate
4. 4
   Otroevaporated down i
5. 5
   workup.WAITThe crude product left as a solid
6. 6
   Otrowas triturated with diethyl ether, suction
7. 7
   Filtraciónfiltered
8. 8
   Otrodried in the air

Procedimiento

A well stirred mixture of 2.34 g (13.2 mmol) 6-chloropyrimidine-4-carboxylic acid chloride, 8.00 g (60.0 mmol) aluminium trichloride and 1.79 g (12.0 mmol) 4-methyl-3H-benzoxazol-2-one was heated to 130° C. for 1.5 h. After cooling to RT the mixture was decomposed with ice water, then extracted with ethyl acetate, the organic phase was dried on sodium sulphate and evaporated down i. vac. The crude product left as a solid was triturated with diethyl ether, suction filtered and dried in the air.

Fuente