Reacción #55545

Ecuación de reacción

ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate

thiourea

water

→

ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate

Rendimiento 53.5%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONThe reaction mixture was treated in a conventional manner

Procedimiento

A mixture of ethyl 4-chloro-3-oxo-2-propargyloxyiminobutyrate (syn isomer, 61 g), thiourea (20 g), sodium acetate 3-hydrate (35.8 g), water (150 ml), and ethanol (180 ml) was stirred at 40° C. for 1.25 hrs. The reaction mixture was treated in a conventional manner to give ethyl 2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetate (syn isomer, 35.6 g).

Fuente