Reacción #555224

Ecuación de reacción

(4-oxo-4-phenylbutyl)-carbamic acid tert-butyl ester

2,5-difluorobenzoic acid hydrazide

HOAc

→

desired product

Rendimiento 101.8%

{4-[(2,5-difluorobenzoyl)-hydrazono]-4-phenylbutyl}-carbamic Acid Tert-butyl Ester

Rendimiento 101.8%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was then heated
2. 2
   Temperaturato reflux
3. 3
   Concentraciónconcentrated

Procedimiento

To a solution of (4-oxo-4-phenylbutyl)-carbamic acid tert-butyl ester (3.2 g, 12.2 mmol) and 2,5-difluorobenzoic acid hydrazide (2.1 g, 12 mmol) in EtOH (40 mL) was added HOAc (0.5 mL). The reaction was then heated to reflux and stirred for 3 days. The reaction mixture was then cooled to room temperature and concentrated to give desired product (5.1 g).

Fuente