Reacción #554568

Ecuación de reacción

H2O

Benzo[b]thiophene-2-ylboronic acid

9-chlorophenanthridin

sodium carbonate

→

9-Benzothienylphenanthridine

Rendimiento 78.0%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaby refluxing under a N2 atmosphere for 5 hours
2. 2
   Extracciónthe mixture was extracted with chloroform
3. 3
   Secadoby drying with sodium sulfate
4. 4
   FiltraciónAfter filtration
5. 5
   Otrothe filtrate was evaporated to dryness under reduced pressure
6. 6
   OtroThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%)

Procedimiento

Benzo[b]thiophene-2-ylboronic acid (884 mg, 5.0 mmol) and 9-chlorophenanthridin (1.0 g, 4.8 mmol) were dissolved in tetrahydrofuran (30 ml), and palladium catalyst (160 mg, 0.14 mmol) and 2M sodium carbonate solution (20 ml) were added, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%).

Fuente