Reacción #554566

Ecuación de reacción

H2O

Benzo[b]thiophene-2-ylboronic acid

1-chloroisoquinoline

sodium carbonate

→

1-Benzothienylisoquinoline

Rendimiento 79.0%

Disolventes

toluene

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaby refluxing under a N2 atmosphere for 5 hours
2. 2
   Extracciónthe mixture was extracted with chloroform
3. 3
   Secadoby drying with sodium sulfate
4. 4
   FiltraciónAfter filtration
5. 5
   Otrothe filtrate was evaporated to dryness under reduced pressure
6. 6
   OtroThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%)

Procedimiento

Benzo[b]thiophene-2-ylboronic acid (997 mg, 5.6 mmol) and 1-chloroisoquinoline (946 mg, 5.8 mmol) were dissolved in toluene (20 ml) and ethanol (10 ml), and palladium catalyst (220 mg, 0.19 mmol) and 2M sodium carbonate solution (20 ml) were added thereto, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O, and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%).

Fuente