Reacción #554558

Ecuación de reacción

methanol

N-methylmorpholine

phosphorus pentachloride

Diphenylmethyl 3-(2-oxotetrahydrofuran-3-ylthio)-7β-phenylacetamidoceph-3-em-4-carboxylate

→

hydrochloride

crude title compound

Diphenylmethyl 7β-Amino-3-(2-oxotetrahydrofuran-3-ylthio)ceph-3-em-4-carboxylate

Disolventes

dichloromethane

dichloromethane

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGcontinued stirring
2. 2
   Temperaturato warm to room temperature
3. 3
   workup.STIRRINGthe solution vigorously stirred for a final 30 min
4. 4
   OtroThe organic solvent was removed by evaporation in vacuo
5. 5
   OtroThe resulting solid was removed from the aqueous phase by filtration
6. 6
   Lavadowas washed with water
7. 7
   SecadoDrying the solid over phosphorus pentoxide in vacuo

Procedimiento

Diphenylmethyl 3-(2-oxotetrahydrofuran-3-ylthio)-7β-phenylacetamidoceph-3-em-4-carboxylate (733 mg) was suspended in dry dichloromethane (10 ml) under an inert atmosphere. The reaction was cooled to -20° C. and treated with N-methylmorpholine (269 μl) followed by a solution of phosphorus pentachloride in dichloromethane (9.5 ml of 40 mgml-1 solution). The now homogeneous solution was stirred at -20° C. for 30 min. Treated with methanol (2.44 ml) and then continued stirring whilst allowing to warm to room temperature. After 30 min. water (3.3 ml) was added and the solution vigorously stirred for a final 30 min. The organic solvent was removed by evaporation in vacuo. The resulting solid was removed from the aqueous phase by filtration and was washed with water and then ether. Drying the solid over phosphorus pentoxide in vacuo gave the crude title compound in the form of its hydrochloride (621 mg). (c) Diphenylmethyl 3-(2-Oxotetrahydrofuran-3-ylthio)-7β-[2-(2-tritylaminothiazol-4-yl)-2-(Z)-methoxyiminoacetamido]ceph-3-em-4-carboxylate.

Fuente