Reacción #5543

Ecuación de reacción

5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine

3-aminopropanol

→

desired product

Rendimiento 55.6%

5-[2-[3-(hydroxy)propylcarbamoyloxy]ethylthio]imdazo[1,2-a]pyridine

Rendimiento 55.6%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was cooled
2. 2
   Lavadowhich was washed with water
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   OtroThen, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20)

Procedimiento

To 5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine (1.10 g, 3.50 mmoles) was added 3-aminopropanol (0.27 ml, 3.52 mmoles) and the mixture was stirred at 120° C. for 1.5 hours. The reaction mixture was cooled by standing and chloroform was added thereto, which was washed with water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. Then, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20) to obtain 575 mg of the desired product (55.6%, colorless crystals).

Fuente