Reacción #5540

Ecuación de reacción

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

phthalic anhydride

→

desired product

Rendimiento 84.8%

5-[2-[2-(carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

Rendimiento 84.8%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturaat reflux for 5 hours
3. 3
   TemperaturaThe reaction mixture was cooled
4. 4
   OtroThe crystals precipitated
5. 5
   Filtraciónwere filtered off
6. 6
   Lavadowashed with chloroform
7. 7
   Otrodried

Procedimiento

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

Fuente