Reacción #55369

Ecuación de reacción

4-Methyl-5-[(2-aminoethyl)thiomethyl]imidazole

1-cyano-2-ethoxy-2-methylaminoethylene

→

title compound

1-Cyano-2-methylamino-2-[2-(4-methyl-5-imidazolyl methylthio)ethylamino]ethylene

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe product was chromatographed on a column of neutral alumina with elution by chloroform/ethyl acetate (1:1)

Procedimiento

4-Methyl-5-[(2-aminoethyl)thiomethyl]imidazole (3.5 g) was added to a solution of 1-cyano-2-ethoxy-2-methylaminoethylene in pyridine (3.1 g) and the solution was stirred for 5 hours at 100°. The product was chromatographed on a column of neutral alumina with elution by chloroform/ethyl acetate (1:1) to give the title compound as a glass.

Fuente