Reacción #55268

Ecuación de reacción

3(R),7-dimethyl octanoic acid ethyl ester

methanol

→

R-(+)-dihydrocitronellic acid

Rendimiento 87.5%

3(R),7-dimethyloctanoic acid

Rendimiento 87.5%

Disolventes

NaOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto give 226 mg

Procedimiento

300 mg. of 3(R),7-dimethyl octanoic acid ethyl ester obtained from example 14 was refluxed in 6 N NaOH (1 ml.), methanol (4 ml.) for 2 hours. It was worked up as in Example 10 to give 226 mg. (87.5% yield) of R-(+)-dihydrocitronellic acid, b.p. 54°/0.4 mmHg. (Kugelrohr), [α]D25 +6.31° (c=5.069, CHCl3).

Fuente