Reacción #5523

Ecuación de reacción

(±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

triethylamine

2,2,2-trichloroethyl chloroformate

→

1-carbamylindoline

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe CH2Cl2 solution was extracted with water and 1N HCl
2. 2
   LavadoThe organic solution was washed with saturated NaHCO3 solution and with brine solution
3. 3
   SecadoThe CH2Cl2 solution was dried (MgSO4)
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

To a solution of (±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (2.3 g, 7.7 mmol) and triethylamine (1.1 ml, 8 mmol) in 90 ml CH2Cl2 under N2 was added dropwise a solution of 2,2,2-trichloroethyl chloroformate. The reaction mixture was stirred at RT for 1 hr. The CH2Cl2 solution was extracted with water and 1N HCl. The organic solution was washed with saturated NaHCO3 solution and with brine solution. The CH2Cl2 solution was dried (MgSO4) and concentrated in vacuo to give 3.3 g of the 1-carbamylindoline.

Fuente