Reacción #55096

Ecuación de reacción

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride

Rendimiento 164.7%

Disolventes

isopropyl alcohol

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 17 hours
2. 2
   ConcentraciónConcentration
3. 3
   Otrofollowed by re-evaporation with water
4. 4
   Otroafforded a residue which
5. 5
   Concentraciónconcentrated to low bulk
6. 6
   Temperaturacooled

Procedimiento

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.

Fuente