Reacción #55095

Ecuación de reacción

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride

Rendimiento 184.6%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 10 hours
2. 2
   TemperaturaFollowing cooling to 15°-20°
3. 3
   Otrothe solid which crystallised
4. 4
   Otrowas collected
5. 5
   Lavadowashed with isopropyl alcohol

Procedimiento

(i)(a) A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in acetic acid (200 ml.) was heated under reflux for 10 hours. Following cooling to 15°-20°, the solid which crystallised was collected and washed with isopropyl alcohol to give 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (45.5 g.), m.p. 189°-192°.

Fuente