Reacción #55094

Ecuación de reacción

hydroxylamine hydrochloride

sodium

ethyl α-naphthylcarbamoylacetate

hydroxylamine

→

α-Naphthylcarbamoylacetohydroxamic acid

Rendimiento 62.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter leaving the reactants in contact for 5 hours
2. 2
   Otrothe mixture is evaporated to dryness in vacuo
3. 3
   Filtraciónthe solution is filtered over charcoal
4. 4
   Otrothe product is precipitated cold with 3 N HCl
5. 5
   Filtraciónfiltered off
6. 6
   Lavadowashed with water
7. 7
   OtroCRL 40,518 is obtained by recrystallisation from ethanol

Procedimiento

19.3 g (0.075 mol) of ethyl α-naphthylcarbamoylacetate are treated with a solution of hydroxylamine, prepared from 5.6 g (0.08 mol) of hydroxylamine hydrochloride and 3.68 g of sodium in 250 ml of methanol. After leaving the reactants in contact for 5 hours, the mixture is evaporated to dryness in vacuo, the residue is taken up in 400 ml of cold water, the solution is filtered over charcoal, and the product is precipitated cold with 3 N HCl, filtered off and washed with water. CRL 40,518 is obtained by recrystallisation from ethanol. Yield: 62%. Melting point: 184°-186° C. (with decomposition).

Fuente