Reacción #5506

ord-856e1c74c5fa4bfaa718c434d3d2dcd8

Ecuación de reacción

CCOC(=O)CC(CCCCCCCCCCC(CC(=O)OCC)C(=O)O)NC(=O)OC(C)(C)C
Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate
ClCCl
methylene chloride
→
CCOC(=O)CC(N)CCCCCCCCCCC(CC(=O)OCC)C(=O)O.Cl
diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride

Reactantes

CCOC(=O)CC(CCCCCCCCCCC(CC(=O)OCC)C(=O)O)NC(=O)OC(C)(C)C
Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate
ClCCl
methylene chloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrohydrogen chloride gas is bubbled through the solution for 15 minutes
  2. 2
    OtroThe sealed reaction
  3. 3
    Otrothe solvent is evaporated

Procedimiento

Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate (3.98 g, 8.40 mmol) is dissolved in methylene chloride (150.0 mL), and hydrogen chloride gas is bubbled through the solution for 15 minutes. The sealed reaction is stirred for 2.5 hours, and then the solvent is evaporated to give diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05244889uspto-grants-1993_09